Abstract
The mucosal immune system contributes to the maintenance of the intestinal mucosal milieu and functions, and to the maintenance of overall body metabolic integrity. Thus the mucosal immune system, like all other homeostatic systems, is necessary to be under neuroendocrine regulation. The interaction between the neuroendocrine system and the immune system has been recognized for many years, and it has recently become apparent that the neuroendocrine system can influence the immune responses, particularly in the mucosal immune system. The intestinal neuroendocrine system consists of an extensive network of the enteric nervous system and specialized epithehal endocrine cells, which constitute a “diffuse neuroendocrine system.” Abnormalities of the neuroendocrine-immune interactions may be important in disease pathogenesis of immune- inflanmiatory disorders in the intestine, including inflammatory bowel disease (IBD) and food allergy. The study of the morphologic, pathophysiologic, and molecular bases of this interaction has become the subject of intensive research. This chapter briefly reviews the information available to date on the advance in this field concerning neuroendocrine-mucosal immune interaction and intestinal immuno-inflammatory disorders.
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