Chapter 11 - Downstream processing of therapeutic bioactive peptide

Abstract

Bioactive peptides have been defined as sequences of 2–20 amino acids residues that can be found in many naturally occurring proteins. Dairy products are considered as rich sources of bioactive peptides with various health-promoting properties such as antithrombotic, antimicrobial, antioxidant, antihypertensive, and immunomodulatory. There is a growing demand for the production and isolation of bioactive peptides derived from milk and milk-based products. These peptides are being proposed as functional ingredients in order to reduce the risk of chronic diseases and promote body health. Therefore much attention has been paid to the characterization of bioactive peptides which isolated or prepared via hydrolysis from milk and dairy products. In order to isolate and fractionate bioactive peptides from milk and dairy products, generally techniques such as selective precipitation, membrane filtration, gel filtration technologies, ion exchange, liquid chromatography, and combination of one or two techniques are used.