Chapter 10 - Sample Handling

Abstract

Prior to the detection, identification, and quantitation of analytes, the important procedures of sample selection, collection, storage/preservation, and transport take place; the term “sample handling” encompasses these procedures. Although these procedures may be considered “preanalytical,” the manner in which they are conducted often determines the validity of the analytical results, and thus it is imperative that they be conducted in an appropriate and accurate manner. Not only must forensic toxicologists be trained in the correct methods of sample handling, but also since generally they are not involved in the collection, initial preservation, and transport of samples to the laboratory, they should be involved in the training of those persons who are involved in these procedures in order to ensure, to the greatest extent possible, that the proper methods are employed. This chapter provides an overview of the criteria utilized for sample selection, the factors that must be considered during sample collection, various strategies of sample preservation, and the guidelines that must be adhered to during sample transport and acquisition.