Abstract
Publisher Summary Kindling is one of the most extensively studied animal models of epilepsy, whereby repeated administration of an initially subconvulsive electrical stimulus results in progressive intensification of stimulus-induced seizure activity. This chapter discusses the : (1) current knowledge on the role of the locus coeruleus (LC) system in kindling epilepsy; (2) describe morphological and functional characteristics of grafted fetal LC neurons; and (3) discuss the data presented in the chapter to indicate that such grafts can retard the development of seizures in kindling epilepsy. Kindling in the noradrenaline (NA)-depleted rat seems to provide a very suitable model for studies on the functional potential of grafted LC neurons. The data presented in the chapter indicates that such neurons can reinstate the seizure-suppressant action normally exerted by the intrinsic LC system. The chapter suggests that grafted neurons can modify the excitability of an epileptic brain region. Intracerebral implantation of inhibitory neurons, such as noradrenergic and GABAergic ones may, therefore, provide a new research strategy to control the generation or spread of seizure activity.
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