Abstract
This chapter focuses on carbohydrate metabolism in case of malaria. The pentose phosphate pathway (PPP) is explained in detail. PPP is the major pathway for recycling nicotinamide adenine dinucleotide (NAD) to nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) and for the production of ribose-5 phosphate that is needed for the synthesis of nucleotides. The function of the PPP depends on the synthesis of nicotinamide-adenine dinucleotide phosphate (NADP) and thiamin pyrophosphate, a coenzyme of the PPP enzyme, transketolase. In red blood cells, the PPP contributes to the maintenance of reduced glutathione (GSH) and prevents the accumulation of methemoglobin. The chapter discusses about the earliest studies of Fulton and Spooner (1956) on plasmodial respiration using radio-labeled glucose with Plasmodium berghei. William Scheibel's comments of 1988 about the early studies on carbohydrate metabolism, the action of antimalarials and some of the anomalous findings are described. The glycolysis and the tricarboxylic acid cycle are elaborated. An overview of pyridine nucleotides and carbon dioxide fixation is also presented.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
