Abstract
Remarkable progress has been made in the study of gastrointestinal (GI) motility, particularly gastric motility, in the last century. This progress in GI motility has proceeded from contributions of a wide range of disciplines with advances in smooth-muscle physiology, electrophysiology, neurohormonal regulation of the GI tract, anatomic/mechanical factors, flow dynamics, as well as basic molecular and cellular biology. Increasingly sophisticated instrumentation, biomedical engineering, and pharmaceutical research have also added to this rich harvest over the past 50 years. A central theme to the progress is the greater understanding of the enteric nervous system, where more than 106 neurons intercommunicate and integrate messages from the gut and brain to organize and coordinate control of GI motility.
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