Chapter 1 - DNA Sequences, Transcription Factors and Chromatin Structure

Abstract

This chapter deals with the fundamental dogma of molecular biology, the DNA producing RNA. The central role of transcription of gene expression renders DNA, an attractive control point, to regulate the expression of genes in particular cell types or in response to a particular signal. It also discusses the basic process of gene expression and its regulation in particular tissues that has led to considerable study of this process focused on the nature of the DNA sequences within individual genes, which were essential for either basal or regulated gene expression. The main aim of chromatin remodeling processes is to expose specific DNA sequences so that these can be targeted by transcription factors involved in the process of gene transcription. The process of transcription and its regulation in particular tissues or in response to particular signals are controlled by short DNA sequence elements located adjacent to the promoter or in enhancers