Abstract
The nuclear Overhauser effect (NOE) is a widely employed technique in the configurational and conformational analysis of natural products. In this chapter, after giving a basic description of the theory behind NOE and ROE experiments, we discuss several technical aspects that should be taken into account by the spectroscopist, such as the proper use of transient NOE experiments like NOESY and ROESY or the use of zero-quantum filters to suppress scalar coupling artifacts. We later discuss the setup of fully quantitative NOE experiments and the treatment of conformationally flexible systems with deconvolution techniques like nuclear magnetic resonance analysis of molecular flexibility in solution, or NAMFIS.
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