Abstract
Publisher Summary The cell surface is central to morphogenetic events. It has been proposed that interactions between the cytoskeleton and the cytoplasmic portions of particular receptors could act to transmit internal cellular states to the cell surface and that, reciprocally, the interactions of such receptors with various ligands could alter the state of the cytoskeleton and affect intracellular signals. This chapter illustrates examples derived from studies in the laboratory, emphasizing properties of cell adhesion molecules (CAMs) and their place dependent expression. It also presents an example of a molecule in the substrate adhesion molecules (SAMs) family, cytotactin, that has interesting mixed functions. Interactions with cytotactin can alter cell shape and motion and also inhibit adhesive events. Finally, the chapter deals with a central question of morphogenesis—that is, how genes control the place-dependent expression of CAMs and SAMs in the embryo. Knowledge about this important process is quite scanty but recent observations on the promoter regions of CAMs and SAMs and their control by homeobox-containing genes promise to help one obtain a satisfactory answer to this question.
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