Abstract
We study a two-dimensional reaction-diffusion equation for calcium oscillation with a pacemaker region. When the pacemaker entrains the whole system, circular waves are observed as a target pattern. However, if the pace of the pacemaker is too fast, the pulse propagation to the outer region sometimes fails in a chaotic manner. We find that spiral waves are spontaneously created at the interface between the pacemaker region and the outer region.
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