Abstract

Perioperative stroke and/or neurological dysfunction, accompanied with significant mortality or incapacitating sequelae, not infrequently complicates cardiac, vascular, or neurological surgery. Indeed a recent study in the Journal showed a remarkably high incidence of perioperative stroke, greater than 1 per 200 such patients.1 Thus, clinical strategies aimed at either protecting the brain or enhancing its tolerance to ischemic or anoxic insults are worthwhile from the clinical point of view. In an article published in this issue of Anesthesiology, Bantel et al.2 provide a fascinating preclinical series of studies examining the mechanisms of brain protection from anesthetics.

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