Changing Trends of Antibiotic Susceptibility Pattern of Salmonella typhi 11 and paratyphi in Recent Isolates

Abstract

Due to lack of proper sanitation measures and clean water typhoid and paratyphoid fever is prevalent in developing counties like Bangladesh. Increasing number of cases of antibiotic resistance as well as multi-drug resistance have been reported in Indian sub-continent. A total of 120 patients selected for this study on the basis of clinical diagnosis. Among them salmonella typhi and paratyphi were isolated in 54 cases by blood culture. Among the isolates 100% sensitivity was present to third generation cephalosporines, gentamycine and carbapenems. Resistance to conventional antibiotics like chloramphenicol, ampicillin, amoxycillin, cotrimoxazole were decreasing which was encouraging. Multi-drug resistant salmonella strains were found in 11.11% cases. S. typhi and paratyphi isolates were highly sensitive to not commonly used antibiotics like gentamycine, ceftazidim and carbapenems. So a careful consideration should be taken before deciding the antibiotic for treatment of enteric fever patients in order to prevent the emergence of antibiotic resistance.