Changing trends in resistance pattern as an alarm by bacteria before it’s too late to treat

Abstract

BackgroundUrinary Tract Infection is one of the most common site of bacterial infection particularly in female accounting for 2o – 3o % of women. UTI in men are less common and primary occur after 5o years of age. It is important to know the causative organisms in the hospital and community for optimum management of UTI. Objectives-To investigate the prevalence and antimicrobial susceptibility of bacterial uropathogens from the patients attending S.N Medical College, Agra. Methods and Material-The retrospective study involved 1022 UTI patient. Out of these 60% were females and 4o% males. Clean catch mid-stream urine from symptomatic UTI cases were analyzed in the microbiology laboratory, S.N Medical College, Agra. Bacterial isolate were identified using biochemical reaction. Antimicrobial susceptibility testing was performed by the KirbyBauer disc diffusion method as described in CLSI guidelines 2010. Results The overall prevalence of UTI was found to be 63.60 % (650/1022). Klebsiella pneumonia (38.46%) and Escherichia coli (42.76%) were most common organism isolates. Conclusion The most effective antibiotic for Escherichia coli and Klebsiella pneumonia were gentamycin, amikacin and cefoperzonsulbactum. Regular monitoring is required to establish reliable information about susceptibility pattern of urinary pathogen for optimal empirical therapy of patient with UTI. Key-words: Antimicrobial Susceptibility Pattern, Prevalence, Urinary Tract Infection.