Abstract
Background. In most hospitals of developing countries, urinary tract infections are treated empirically because of lack of culture facilities. This leads to emergence of multiresistant uropathogens. Culturing and drug susceptibility testing are essential to guide therapy. Objectives. To assess changing prevalence and resistance pattern of uropathogens to commonly used antibiotics in a two-year study period. Methods. Urine specimens were collected and cultured. Uropathogens were identified by standard methods and tested for antibiotics resistance. Data were analyzed using SPSS version 16 statistical sofware. P value < 0.05 was considered statistically significant. Results. The commonest isolates in both the previous and present studies were E. coli, Klebsiella, CoNS, S. aureus, Proteus, and Citrobacter species. Previous isolates of Enterobacteriaceae were 100% sensitive to ciprofloxacin, whereas present isolates developed 31% to 60% resistance to it. Previous isolates were less resistant to gentamycin than the present ones. Multiresistance isolates were predominant in present study than previous ones. Conclusion. E. coli was predominant in the two study periods. Present isolates were more resistant than previous ones. Some previous isolates were 100% sensitive to ciprofloxacin, whereas present isolates were increasingly resistant. Ciprofloxacin and gentamicin have been recommended for empiric treatment of urinary tract infections.
Highlights
In most hospitals of developing countries, urinary tract infections are treated empirically because of lack of culture facilities
All gram negative uropathogens were resistant to 25–60% ciprofloxacin, while 53.8% S. aureus and 54.3% CoNS were resistant to this antibiotic
This study has showed more resistant E. coli and Klebsiella spp. and S. aureus and CoNS to seven antibiotics tested over a ten-year period
Summary
In most hospitals of developing countries, urinary tract infections are treated empirically because of lack of culture facilities. This leads to emergence of multiresistant uropathogens. To assess changing prevalence and resistance pattern of uropathogens to commonly used antibiotics in a twoyear study period. The prevalence of urinary tract pathogens and their resistance to the different antibiotics may have changed over the years in the study area. The objectives of this study were to assess the changing prevalence and resistance patterns of the uropathogens to commonly used antibiotics in a two-year study period
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