Changing Patterns and Present Status of Female Breast Cancer in China over 30 Years.

Abstract

Abstract Introduction: As a metropolis with rapid social and economic development over the past three decades, Shanghai has a breast cancer incidence that surpasses all other cancer registries in China.Methods: In order to estimate the regular changing patterns of female breast cancer in urban Shanghai, population-based incidence data from 1975 to 2004 were studied. In addition, a one-hospital-based in-patient database of 9709 female breast cancer patients treated surgically between Jan-1990 and Dec-2008 were reviewed, retrospectively.Results: We observed that breast cancer incidence increased dramatically over the past 30 years and documented a peak incidence represented by the middle-age group (45-59 yrs), which emerged in the last 20 years. The incidence peak moved from the 40-44 year group in the previous two decades to the 50-54 year group in the most recent decade. Median age at diagnosis was earlier in Shanghai than in the western countries, although it increased from 47.5-yr in 1990 to 51-yr in 2008. Considerably higher exposure to reproductive risk factors and relatively fewer hormone-dependent cases were observed- only 49.2% of breast cancers were estrogen receptor(ER) positive, 46.1% were progesterone receptor positive. The proportion of asymptomatic cases detected by screening gradually increased, as well as that of early-stage cases (from 78.6% in 1990 to 87.9% in 2008 and carcinoma in situ (14.9% in 2008). Analysis of surgical treatment patterns suggested a trend of less-invasive options.Conclusions: Rapid socioeconomic growth and birth-control policies have revealed some unique risk factors, which pushed the pattern of breast cancer in Shanghai towards that of the western countries. Age of peak incidence as well as median age at diagnosis increase with time, which suggests that increased incidence trending along with increasing age will be observed in the future. The middle-age group born after 1950s would be involved in current birth-control policies and they are also the cohorts related to the incidence boom. Thus specific screening protocols should be refined for the Chinese population, considering not only increasing age but also birth cohorts. Improvements in breast cancer detection provide patients with more opportunities for less invasive treatment options. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2058.