Abstract
SUMMARY Ten adult ewes, including four pregnant ones, were treated with either 1·0 or 1·5 g cyclophosphamide administered intravenously as a means of chemical shearing. Blood samples were collected at various time intervals for haematological and serum protein analyses. Each of the serum samples was fractionated through protein-A Sepharose CL-4B gel and then analysed by polyacrylamide electrophoresis. This method detects changes in the serum protein pattern as early as 2 h post cyclophosphamide injection. The changes were characterized by elevated levels of several protein fractions especially albumin and the alpha-globulins. Later, insignificant changes in the blood constituents could be detected. Single injection of the drug resulted in complete loss of the wool coat; otherwise the animals remained asymptomatic. No effects on the foetuses were found.
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