Abstract
The current knowledge on how protein–protein interactions regulate the function of transcription factors (TFs) has remained limited due to an incomplete knowledge of their interaction partners. In their recent work, Chen and colleagues (Li et al, 2015) analyse the interactome of 56 TFs and reveal distinct chromatin-associated and soluble TF complexes.
Highlights
The current knowledge on how protein– protein interactions regulate the function of transcription factors (TFs) has remained limited due to an incomplete knowledge of their interaction partners
This is especially true for TFs that control gene expression largely by recruiting other proteins to chromatin
Li et al (2015) address this important issue by systematically uncovering the interactome of 56 mammalian TFs. They investigate the soluble and chromatin-associated cellular fractions and demonstrate that TFs bind to different partner repertoires when they are located on or off chromatin (Fig 1)
Summary
Changing partners: transcription factors form different complexes on and off chromatin. The current knowledge on how protein– protein interactions regulate the function of transcription factors (TFs) has remained limited due to an incomplete knowledge of their interaction partners. In their recent work, Chen and colleagues (Li et al, 2015) analyse the interactome of 56 TFs and reveal distinct chromatin-associated and soluble TF complexes. A protein’s function is generally modulated by its interactions with other proteins, and these interactions can potentially change depending on the subcellular location of the protein This is especially true for TFs that control gene expression largely by recruiting other proteins to chromatin. We have built up a piecemeal understanding of TF interactions through the identification of binary interactions with a range of co-regulatory
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