Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

Abstract

Objective: We examined the association between uric acid and glycemic status by the aspects of age and sex. Methods: The retrospective was performed study at Okmeydani Educate and Research Hospital. All data were obtained from the patient records. Only one sample of HbA1c or glucose measurement within a year was included. To evaluate the pattern of glucose control, we categorized the patients according to HbA1c levels and grouped them according to a range of values. HbA1c was measured by high performance liquid chromatography, routine biochemistry parameters were determined by photometric method. Results: Serum uric acid levels showed an increasing trend with the age in female group and this trend became significant after 30 years old (p<0.001). The significant effect of HbA1c and gender on uric acid levels were determined in the subjects having no renal failure. There was a significant increase of uric acid levels in prediabetics than normal group and decrease in unregulated diabetics. But in both sex groups the pattern of changing was different. Conclusion: In conclusion, we found that age is an important factor examining the serum uric acid levels of female subjects. The peak values of serum uric acid were detected in prediabetic group in males but in females this peak point was diabetic group. J Clin Exp Invest 2016; 7 (1): 1-6 Key words: Diabetes mellitus, uric acid, age, gender