Abstract
Data from a limited amount of human and animal experimentation suggests that dietary change targeted at altering membrane fatty acid composition. and at enhancing antioxidant defences, may modulate cytokine biology in a beneficial way (4). Dietary fish oil supplementation reduces the ability of monocytes from healthy subjects and rheumatoid patients for producing IL1 and TNF. Fats rich in n-3 PUFAs (fish oil), poor in n-6 PUFAs (coconut oil, olive oil and butter) or rich in monounsaturated fatty acids (butter and olive oil), in common, reduce the anorexic effects of TNF and endotoxin in rats. The fats exhibit differing modulatory effects on other physiological effects of these inflammatory agents (4.5). In animal studies evidence is accumulating that conditions in which free radical production is exacerbated, or in which antioxidant defences are reduced, enhances TNF production in response to inflammatory agents. Synthetic antioxidants prevent this phenomenon (4).
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