Abstract
The effect of intravenous injection of pituitrin P (0.1 ml/kg) on the kidneys was studied in dogs receiving analgesics (acetylsalicylic acid 100 mg/kg; sodium salicylate 200 mg/kg; phenacetin 80 mg/kg) for 6 months. Under the influence of these analgesics the response of the kidneys to injection of pituitrin was altered. The inhibition of diuresis was less marked and excretion of osmotically free water was greater in the experimental dogs than in the controls. These changes indicate a decrease in the sensitivity of the tubular epithelium to the antidiuretic hormone under the influence of the analgesics.
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