Changes of visfatin, acylation stimulated protein level in simple obese children and their clinical significances

Abstract

Objective To explore the relationship between visfatin, acylation stimulated protein(ASP) and the incidence of childhood obesity and the significance of them in diagnoses and therapy of children's obesity. Methods Eighty-six children(57 boys and 29 girls)including 40 obese children, 22 overweight children and 24 healthy control children were recruited with ages ranged 7-15 years.Serum visfatin and ASP levels were determined by enzyme linked immunosorbent assay(ELISA). Results 1.Compared with healthy and overweight children, serum visfatin level was significantly higher in obese children(P<0.05); Compared with healthy children and overweight children, serum ASP levels were significantly higher in obese children(P<0.01, 0.05). There were no differences of serum visfatin and ASP levels between healthy and overweight children.2.The body mass index(BMI), total cholesterol(TC), triglycerides(TG), low density lipoprotein-cholesterol(LDL-C), fasting plasma glucose(FPG), fasting insulin(FINS), insulin resistance index of the obese children were higher than those of the healthy children(all P<0.05); the high density lipoprotein-cholesterol(HDL-C) and insulin sensitivity index of the obese children were lower than those of the healthy group(all P<0.05). The BMI, FINS, insulin resistance index of the obese children were higher than those of the overweight children(P<0.01).3.Correlation analysis: serum visfatin, BMI and TG were positively correlated(r=0.218, P<0.05; r=0.500, P<0.01, respectively). ASP and BMI, TC, TG were positively correlated(r=0.268, P<0.05; r=0.250, P<0.05; r=0.427, P<0.01, respectively). Conclusions In simple obesity children, there was a significant change in serum visfatin and ASP, and visfatin and ASP were involved in the disorder of lipids metabolism in obese children.Serum visfatin and ASP levels can be used as a new indicator to evaluate the risk of childhood obesity trends and future evaluation of diabetes and cardiovascular diseases. Key words: Visfatin; Acylation stimulated protein; Obesity; Child