Changes of thyroid autoantibodies and its relationship with dyslipidaemia in children with Turner syndrome

Abstract

Objective To investigate the changes of thyroid autoantibody (TAA) in children with Turner syndrome(TS), and its association between TAA and thyroid dysfunction, age, karyotype and dyslipidaemia. Methods Thirty-two patients with TS diagnosed by chromosome analysis hospitalized at Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University from July 2007 to July 2015 were divided into 2 groups based on TAA-positive or TAA-negative, then the thyroid dysfunction, the age, the karyotype and the lipid metabolism were compared between 2 groups. Results Of the 23 cases of TAA-positive girls(23/32 cases, 71.88%), 9 girls(39.13%) suffered from thyroid dysfunction; of the 9 cases of TAA-negative girls (9/32 cases, 28.12%), 3 girls(33.33%) had thyroid dysfunction.As compared with the girls in TAA-negative group, the age in TAA-positive group was significantly higher[(12.08±2.90) years old vs.(8.89±4.17)years old], and the difference was significant(t=101.500, P=0.047). The patients were divided into 4 age groups: 0-5 years old, >5-10 years old, >10-15 years old and >15 years old; the rates with TAA-positive were 25.00% (1/4 cases), 75.00%(6/8 cases), 82.35% (14/17 cases) and 66.67%(2/3 cases) respectively.Twenty patients received the lipid metabolism test, and 11 cases(11/20 cases, 55.00%) of them suffered from dyslipidaemia, 9 cases of them were TAA-positive (9/11 cases, 81.82%), and 2 cases were TAA-negative(2/11 cases, 18.18%). The differences in the prevalence of dyslipidaemia between the 2 groups were significant (χ2=4.848, P=0.028). There was no significant difference in the numbers of TAA-positive cases among different karyotypes(χ2 =4.246, P=0.120). Conclusions Patients with TS are prone to suffer from thyroid dysfunction and dyslipidaemia.Timely detection of TAA and thyroid function is recommended, as well as the lipid metabolism if necessary. Key words: Turner syndrome; Thyroid autoantibody; Dyslipidaemia