Changes of the serum creatine phosphokinase in total hip arthroplasty in Vietnamese patients

Abstract

BackgroundWe analyzed biochemical markers of muscle damage in patients treated with total hip arthroplasty with minimally invasive and standard posterolateral approach to providing objective evidence of the local soft-tissue injury at the time of arthroplasty. MethodsSixty-one patients in group one treated with minimally invasive total hip arthroplasty through an approach less 9 cm length and fifty-three patients in group two treated with the same procedure through an approach more than 9 cm length. Serum creatine phosphokinase (CPK) levels were measured preoperatively and on postoperative days 1, day 2 and 5. ResultsThe levels of the markers of muscle damage were increased in both group. The rise in the CPK level on postoperative day 1 in both group was 2.5–3 times higher than preoperative CPK and were slightly decreased on the next few days. There were no significant differences between the two cohorts of changes of CPK level. ConclusionsThe objective measurement of muscle damage marker provides an unbiased way of determining the immediate effects of surgical intervention in patients treated with total hip arthroplasty.