Abstract
Serum total lipids, lipid phosphorus, total cholesterol, five subfractions of cholesterol esters, lysolecithin, sphingomyelin, lecithin, phophati-dylethanolamine, free fatty acids, free cholesterol, triglycerides and esterified cholesterol were analysed in 108 cases of multiple sclerosis subdivided into four groups according to the activity of clinical symptoms of the disease and compared with 34 control blood donors. A decrease of cholesterol linoleate and an increase of tri- and tetra-unsaturated fatty acid cholesterides were found to be constant changes in the progressive stages of multiple sclerosis. Other alterations of lipid composition and concentration were not substantial.
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