Changes of soluble triggering receptor expressed on myeloid cells-1 and lactate in children with purulent meningitis

Abstract

Objective To discuss the diagnosis significance of soluble triggering receptor expressed on myeloid cells-1(STREM-1) and lactate in children with purulent meningitis, and to investigate the changes of STREM-1, lactate in cerebrospinal fluid(CSF) of purulent meningitis before and after treatment. Methods Dry chemical method and enzyme linked immunosorbent assay( ELISA)were used to measure STREM-1 and lactate levels in CSF of purulent meningitis group(24 cases), viral meningitis group(27 cases), CSF normal group(25 cases) and purulent meningitis after treatment group(22 cases). Results 1.STREM-1 and lactate levels in CSF were higher in patients with purulent meningitis than in those with viral meningitis and CSF normal group(all P<0.05).2.STREM-1 and lactate levels in CSF were higher in patients with purulent meningitis before treatment than those after treatment(all P<0.05).3.The area under the curve(AUC) of STREM-1 in CSF was 0.891, and at a cutoff level of 27.86 ng/L STREM-1 yielded a sensitivity of 80.8% and specificity of 75.0%; the AUC of CSF lactate was 0.940, and at a cutoff level of 1.75 mmol/L lactate yielded a sensitivity of 90.4% and specificity of 83.3%. Conclusions 1.STREM-1 and lactate were asso-ciated with bacterial infection, they have considerable diagnostic values in purulent meningitis.2.STREM-1 and lactate maybe worthless in differential diagnosis of purulent meningitis when treated by effective antibiotics.3.The decline of STREM-1 and lactate in CSF prompts the control of infection and good prognosis. Key words: Purulent Meningitis; Viral meningitis; Soluble triggering receptor expressed on myeloid cells-1; Lactate; Diagnose; Differential diagnosis