Changes of serum irisin levels in postmenopausal breast cancer women

Abstract

Breast cancer (BC) is a malignant neoplasm characterized by abnormal cell growth of breast tissue in an uncontrolled pattern and their ability to infiltrate and invade normal tissue locally. Irisin plays an important role in the occurrence, development, and metastasis of different tumors. The aim of this study to evaluate the changes of serum levels of irisin in postmenopausal breast cancer women and compared with control group. Serum samples were collected from 90 women were 30 of these women were control and 60 women were breast cancer patients attending to cancer center in Kirkuk city- Iraq from November 2021 to April 2022 . Postmenopausal breast cancer women ages were above 46 years, who were proved to be suffering from breast cancer whether a unilateral or bilateral breast affected who agree to participate in this study. Irisin levels for postmenopausal breast cancer women were (77.11±25.91) ng/ml and control (17.35±5.05) ng/ml respectively with a highly significant increase (P≤0.01) when compare with healthy control. These results suggest that irisin can be used in the early diagnosis, differential diagnosis, and prognosis of breast cancer.irisin