Abstract
Objective:To investigate the correlations of levels of serum insulin-like growth factor-1 (IGF-1) and endothelin-1 (ET-1) with cytokines including interleukin (IL)-18, IL-6 and high-sensitivity C-reactive protein (hs-CRP) and bone material density in patients with osteoporosis d.Methods:Eighty patients with osteoporosis who were treated in our hospital from April 2016 to October 2017 were selected as observation group, and 60 healthy elderly people who received physical examination in our hospital in the same period were selected as control group. The serum levels of IGF-1 and ET-1 were detected using enzyme-linked immunosorbent assay. The bone material density of the lumbar vertebra, tibial neck and Ward’s triangle of every research subject was measured using dual-energy x-rays absorptiometry. The correlations between variables were analyzed using Pearson correlation analysis.Results:The level of IGF-1 in the observation group was lower than that in the control group, and the level of ET-1 in the observation group was higher than that in the control group (P<0.05). The levels of interleukin (IL)-18, IL-6 and high-sensitivity C-reactive protein (hs-CRP) in the observation group were significantly higher than those in the control group (P<0.05). Bone mineral density of lumbar vertebra, tibial neck and Ward triangle in the observation group was significantly lower than that in the control group (P<0.05); the IGF-1 level of osteoporosis patients was negatively correlated with IL-18, IL-6, hs-CRP levels and positively correlated with bone mineral density; the ET-1 level was positively correlated with IL-18, IL-6, hs-CRP levels and negatively correlated with bone mineral density.Conclusion:Patients with osteoporosis have decreased level of IGF-1 but increased level of ET-1, and they are closely related to cytokines and bone mineral density and may participate in the pathogenesis of osteoporosis.
Highlights
Osteoporosis, a systemic bone metabolic disease, is mainly induced by bone density reduction and bone microstructure destruction caused by the abnormal metabolism of calcium and phosphorus in the body.[1,2] An epidemiological study shows that 223~333 among 10 thousand people may have osteoporosis.[3]
Analysis on correlation of serum levels of IGF1 and ET-1 with cytokines and bone mineral density showed that serum levels of insulin-like growth factor-1 (IGF-1) were in a significant negative correlation with levels of IL-18, IL-6 and high-sensitivity C-reactive protein (hs-CRP), but in a significant positive correlation with bone mineral density; the serum level of ET-1 was in a significant positive correlation with levels of IL-18, IL-6 and hs-CRP, but in a significant negative correlation with bone mineral density (Table-IV)
This study found that the serum levels of IGF-1 and ET-1 had obvious abnormal expression in patients with osteoporosis, the expression level of IGF-1
Summary
Osteoporosis, a systemic bone metabolic disease, is mainly induced by bone density reduction and bone microstructure destruction caused by the abnormal metabolism of calcium and phosphorus in the body.[1,2] An epidemiological study shows that 223~333 among 10 thousand people may have osteoporosis.[3] The incidence of osteoporosis is higher in middle-aged and elderly people or in people with endocrine hormone metabolism disorders.[4] A foreign study show that about 15% of white people in their 50s and 70% of white people over the age of 80 are affected, and women are more common than men.[5] The diagnostic results. Pak J Med Sci May - June 2019 Vol 35 No 3 www.pjms.org.pk 691 in developed countries indicated that 2%~8% of males and 9%~38% of females had osteoporosis.[6] As population aging becomes more and more serious in China, the prevalence of osteoporosis is increasing year by year. Osteoporosis has become an important cause of fracture and even death of patients, but there is no effective method for clinical diagnosis of osteoporosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
