Changes of serum Golgi protein-73 before and after interventional therapy and operation in patients with primary liver carcinoma

Abstract

Objective To investigate the changes of serum Golgi protein-73 (sGP73) in patients with primary liver carcinoma (PLC) before and after interventional therapy and operation.Methods Enzyme linked immunosorbent assay (ELISA) was used to detect the level of serum sGP73 in 33 cases of normal control subjects and 65 cases of PLC,and sGP73 levels in 24 cases of stage Ⅱ PLC pre-and post-interventional therapy,and 22 cases of stage Ⅰ PLC pre-and post-operation were compared.Results The sGP73 levels were elevated in all subgroups of patients with PLC [(212.19 ± 18.10) μg/L] compared to the controls [(52.60 ±3.74) μg/L,P ＜0.01].sGP73 was correlated with clinical stage,but not with sex and age.The sGP73 levels in stage Ⅲ [(228.79 ± 11.99) μg/L] were higher than those in stage Ⅱ [(216.21 ±8.10) μg/L,P＜0.01],those in stage Ⅱ were higher than those in stage Ⅰ [(192.03 ± 8.26) μg/L,P ＜0.01],and those in stage Ⅰ were higher than those in normal control subjects (P ＜0.01).The sGP73 levels were remarkably reduced in patients with PLC after interventional therapy or operation (P ＜ 0.01).Conclusion These results suggest that detection of sGP73 is helpful for evaluating treatment response and prognosis of PLC. Key words: Golgi protein-73 ; Primary liver carcinoma ; Interventional therapy