Abstract
Objective To investigate the changes of serum growth hormone (GH)/insulin-like growth factor- I (IGF- I ) in patients with traumatic long bone fractures and the related clinical signifi- cance. Methods Twenty-one patients with traumatic long bone fractures from the same trauma care center treated between November 2009 and April 2010 were enrolled in the study. There were 14 males and 7 females, at age range of 22-60 years (mean 45.0 years). Seventeen patients (81%) were with closed trauma and four (19%) with open trauma. Enzyme Linked Immunoadsorbent Assay (ELISA) was used to determine the levels of serum GH and IGF- I within 14 days after fractures and the relationship between changes of GH-IGF- I axis and injury severity score (ISS) was further analyzed. Eight patients with normal GH/IGF- I were set as control group. Results The GH level in the peripheral blood was significantly higher at day 1 after fractures (P 〈 0.05 ), and rapidly declined and stabilized at day 5 compared with the control group. The GH level in the patients with ISS≥ 18 points was significantly higher than that in those with ISS 〈 18 points at day 1 after fractures (P 〈0.05). The IGF- I level in the peripheral blood in the patients with ISS≥ 18 points was significantly higher than that in those with ISS 〈 18 points at days 5-10 after fractures (P 〈 0.05). Conclusion The hypothalamus GH-IGF- I axis plays an important role in early metabolism and fracture healing during the acute phase of traumatic long bone fractures. Key words: Fractures, extremities; Growth hormone; Insulin-like growth factor- I
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