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Abstract
Objectives:To investigate the correlation of serum ficolin-3 and C5b-9 with cardiac function and NT-proBNP in patients with heart failure.Methods:Sixty patients with heart failure admitted to the Baoding First Central Hospital from May 2019 to May 2020 were selected and divided into three groups according to the classification of New York Heart Association (NYHA). Patients with NYHA grade II, III, and IV were included into group A, B, and C, respectively. Among the population undergoing physical examination at the same time, 20 cases with no significant difference in age and gender from the experimental group were selected as the control group (Group-N), and their clinical data were recorded. The serum levels of ficolin-3, C5b-9 and NT-proBNP in each group were detected and compared.Results:The serum concentrations of ficolin-3 and C5b-9 in Group N were significantly different from those in Group A, B and C (p<0.05), the difference between Group C and Group A and B was statistically significant (p<0.05), there was no significant difference between group A and B (p>0.05). The correlation analysis between serum ficolin-3 and NT-proBNP showed that serum ficolin-3 was negatively correlated with NT-proBNP (r=-0.606, p<0.0001), while the correlation analysis between serum C5b-9 and NT-proBNP showed that serum C5b-9 was positively correlated with NT-proBNP (r=0.499, p<0.0001). According to the etiology of heart failure, patients with heart failure were divided into coronary heart disease (25 cases), dilated cardiomyopathy (15 cases) and others (20 cases). The differences of ficolin-3 and C5b-9 among patients were compared, and there was no statistical difference (p<0.05).Conclusion:Ficolin-3 was inversely associated with the severity of heart failure, while C5b-9 was positively associated with the severity of cardiac impairment. Both of them have nothing to do with the etiology of heart failure.
Highlights
Heart failure (HF) is the common end of a variety of heart diseases,[1] which seriously threatens human health
Ficolin-3 is a promoter of the complement lectin pathway, which can activate the lectin pathway of complement so that the complement system is fully activated, and the terminal complement complex C5b-9 is eventually formed
Cardiomyocytes in patients with heart failure are characterized by a variety of death mechanisms, including necrosis, apoptosis, tumor and autophagy, etc., which are related to complement activation.[9,10,11]
Summary
Heart failure (HF) is the common end of a variety of heart diseases,[1] which seriously threatens human health. It has been shown in a large number of studies that complement exerts an important role in the occurrence and development of HF.[2,3,4,5] Ficolin-3 is a promoter of the complement lectin pathway, which can activate the lectin pathway of complement so that the complement system is fully activated, and the terminal complement complex C5b-9 is eventually formed. Most of the studies on ficolin-3 have focused on diseases such as autoimmune system and inflammation.[6,7,8] In this study, the role of ficolin-3 and C5b-9 in heart failure was studied to explore the relationship between ficolin-3 and C5b9 and cardiac function in patients with heart failure, so as to provide new methods for the diagnosis and prognosis of heart failure, and to conceive new treatment ideas and schemes for delaying the progression of heart failure
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