Changes of serum ferritin and 25-(OH) vitamin D3 in cranial neuropathy diabetic patients

Abstract

Objective To observe the changes of serum ferritin and 25-(OH) vitamin D3 in patients with diabetic cranial neuropathy. Methods There were 50 patients without diabetic Cranial neuropathy, 46 patients with diabetic cranial neuropathy, and 40 cases of normal control group. The changes of serum ferritin and 25-hydroxy vitamin D3 were observed in each group. The correlation between two indexes and the correlation with diabetic cranial neuropathy were analzyzed. Results The serum ferritin levels in diabetic group and diabetic neuropathy group were significantly higher than those in normal control group (P<0.01), and its level in patients with diabetic cranial neuropathy [(687.54±65.38)ng/ml] was significantly higher than that of patients without diabetic cranial neuropathy [(497.28±46.39)ng/ml, P<0.01]. The serum 25-(OH) vitamin D3 levels in the diabetic group and diabetic neuropathy group were lower than those in the control group (P<0.01), and its level in patients with diabetic cranial neuropathy [(26.45±8.93)nmol/l] was significantly less than that of patients without diabetic cranial neuropathy [(37.19±9.74)nmol/L, P<0.01]. Serum ferritin levels were positively correlated with 25- (OH) vitamin D3 (r=-0.59, P<0.01). Multivariate unconditional Logistic regression analysis showed that diabetic neuropathy was negatively correlated with 25-(OH) vitamin D3 (P<0.05). Conclusions The increases of serum ferritin and 25-(OH) vitamin D3 are closely related to the occurrence and development of diabetic cranial neuropathy, which provides the theoretical basis for clinical intervention therapy. Key words: Diabetic neuropathies/ME; Cranial nerve diseases/CO/ME; Ferritins/ME; Calcitriol/ME