Abstract
BackgroundThe present study aimed to study the relationship between serum 25 hydroxyvitamin D3(25(OH)D3) and insulin-like growth factor-1 (IGF-1) and thyroid nodules.MethodsTwo hundred eighty-nine cases with thyroid nodules and 109 health subjects (control group) who admitted to the Hebei General Hospital during June 2016 to December 2016 were included in the study. Basic clinical information (age, sex, thyroid function, liver and kidney function, hypertension history, etc.) of patients were collected. Serum 25(OH) D3 and Serum IGF-1 were detected by electrochemiluminescence and radioimmunoassay methods, respectively. The relationship between the above-mentioned factors and thyroid nodules was statistically analyzed.ResultsSerum 25(OH)D3, IGF-1, fasting blood glucose (FBG), total cholesterol (TC), waist circumference (WC), total triiodothyronine (TT3), total thyroxine (TT4), hypertension history, and drinking history were significantly different between the nodules group and the control group (P < 0.05). Logistic regression analysis showed that there was a negative correlation between thyroid nodules and levels of 25(OH)D3, IGF-1, TT3, as well as a positive correlation with FBG, TC, TT4, and hypertension. There was a positive correlation between IGF-1 and serum 25(OH)D3 in thyroid nodules (P < 0.05). After correcting the aforementioned factors, high-level of serum 25(OH)D3 was significantly correlated with the decreased incidence of thyroid nodules.ConclusionsThe incidence of thyroid nodules is relatively lower in a high-level of serum 25(OH)D3, and serum 25(OH)D3 may be a direct protective factor for thyroid nodules. Serum IGF-1 can be one of the indirect protective factors for thyroid nodules as well.
Highlights
The present study aimed to study the relationship between serum 25 hydroxyvitamin D3(25(OH)D3) and insulin-like growth factor-1 (IGF-1) and thyroid nodules
The main factors including fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were analyzed by an automatic biochemical analyzer, and serum 25(OH)D3, fasting insulin (FINS) and thyroid function were measured by electrochemiluminescence, and serum IGF-1 was determined by radioimmunoassay
The results showed that the serum 25(OH)D3 level in the nodular group was lower than that in the control group (9.86 ± 6.66 vs. 12.74 ± 7.13 ng/L) (P < 0.001); the serum IGF-1 level in the nodular group was lower than that in the control group (111.10(81.53, 165.44) vs. 192.65(96.38, 313.49) ng/L), and the differences were statistically significant (P < 0.001) (Table 1)
Summary
The present study aimed to study the relationship between serum 25 hydroxyvitamin D3(25(OH)D3) and insulin-like growth factor-1 (IGF-1) and thyroid nodules. Thyroid nodules is an independent lesion in the thyroid gland, and it is one of the common diseases on the endocrine system. With the popularization of health examination and the appearance of thyroid color Doppler as a general examination item, the detection rate of several asymptomatic thyroid nodules is increasing, and individuals pay further attention to it. The relationship between the changes of serum vitamin D3 levels and the thyroid nodules is not still clear. IGF-1 probably plays an important role in the genesis and development of certain solid cold thyroid nodules, including papillary thyroid carcinomas, nodular goiters, and follicular adenomas [3]. High 25(OH)D3 level may be a factor in reducing cell proliferation and inducing apoptosis through complementary pathways or mechanisms
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
