Changes of pulmonary ventilation function after inhalated salbutamol and ipratropium bromide in patients with chronic obstructive pulmonary disease

Abstract

Objective To investigate the different changes of pulmonary ventilation function after inhaled both salbutamol and ipratropium bromide and after inhaled single salbutamol in patients with chronic obstructive pulmonary disease (COPD).Methods The pulmonary function after inhaled combined bronchodilators in 43 patients with COPD were analyzed by prospective study,and as control,the classic bronchodilation test data of 180 patients with COPD were retrospectively collected.Results The positive rates of hronchodilation test after inhaled combined bronchodilators 30 minutes in combined bronchodilators group and its'GOLD Ⅱ patients were 34.9% and 43.5%,which significantly greater than 17.25% and 18.4% of single bronchodilators group and its GOLD Ⅱ patients (P＜0.05).The percentages of patients whose FEV_1 improvement rate≥20.0% and ＜10.0% were 37.2% and 39.5% after inhaled combined bronchodilators 30 minutes in combined bronchodilators group (P>0.05),while in single bronchodilator group the percentages were respectively 17.8% and 53.9% in same FEV_1 improvement rate ranges (P＜0.05).The percentages of patients in two groups whose FEV_1 improvement rate 20.0% were significantly different each other (P＜0.001).△FEV_1 and △FVC after inhaled combined broncbodilators 30 minutes in combined broncbodilators group and its GOLDⅡ patients were greater than those of single bronchodilator group and its GOLDⅡ patients (P＜0.05).There were significant positive correlation between △FEV_1 and △FVC in two groups,along with the progression of COPD,the correlation gradually strengthened in combined bronchodilators group but gradually weakened in single bronchodilator group.Conclusions The patient with COPD had more obvious bronchial reversibility after inhaled both salbutamol and ipratropium bromide than after inhaled single salbutamol,moreover,the duration of drug effect were longer in combined bronchodilators group patients. Key words: Chronic obstructive pulmonary disease; Salbutamol; Ipratropium bromide; Bronchodilation test