Changes of plasma insulin glucagon and somatostatin in portal blood and morphological changes of islets of Langerhans after hepatectomy in dogs.

Abstract

Hybrid adult male dogs were laparotomized before, one week after and one month after 40% hepatectomy. At the same time, an intravenous glucose tolerance test was done (IV-GTT) and pancreatic tissues were removed and examined by PAP staining. The following results were obtained: Carbohydrate metabolism was disturbed and plasma insulin levels were low one week after surgery, but B-cell granulations was at the preoperative level. It seemed that hypersomatostatinemia suppressed insulin release from B cells. Carbohydrate metabolism was restored to normal and the plasma insulin response was increased one month after surgery. Islets of Langerhans cells were hypertrophic and increased after surgery, particularly D cells.