Changes of nucleic acids and protein concentrations intissue of leukemic and pyridoxine-deficient AKR mice.

Abstract

1. Concentrations of nucleic acids and proteins, and the activity of aspartyl transcarbamylase of the thymus, spleen, liver and kidney have been studied in normal, leukemic and pyridoxine-deficient mice of AKR strain.2. There are significantly more RNA concentrations of the thymus, spleen and liver in leukemic mice than in the corresponding tissues in normal mice, whereas DNA concentration did not vary in the corresponding tissues. In pyridoxine-deficient mice, DNA was less in the thymus, spleen and liver than in normal mice, while RNA concentrations of the thymus in pyridoxinedeficient mice were drastically decreased than those of normal mice.3. Concentrations of proteins of the thymus, liver and kidney were less in pyridoxine-deficient mice than in normal mice.4. The activity of aspartyl transcarbamylase in the thymus and liver decreased in both leukemic and pyridoxine-deficient mice over normal control.