Abstract
Objective To investigate the effect of asphyxia in perinatal period on NK cell and T-lymphocyte subsets levels in preterm infants.Methods Flow cytometers was used to detect the venous blood T-lymphocyte subsets levels of 31 preterm infants with mild asphyxia and 25 premature infants with severe asphyxia at 2 hours after birth.At the same period,30 preterm infants without asphyxia hospitalized in our department were enrolled as control group.Results Compared with the control group and the mild asphyxia group,CD3-/CD16+ CD56+,CD3+,CD4+,CD4/+ CD8+ of the severe asphyxia group significantly decreased(P ＜ 0.05) ; CD3-/CD16+ CD56+ and CD3+,CD4+,CD4+/CD8+ of the mild asphyxia group were lower than those in the control group,there were significant differences (P ＜ 0.05).There was no significant difference in each indexes between mild and severe asphyxia group and control group,but both of them were higher than that in the control group (P ＞ 0.05).Conclusions Asphyxia can cause disturbance of T-lymphocyte subsets in preterm infants and the more severe of asphyxia,the more dramatic change of NK cell and T-lymphocyte subsets have been found. Key words: Neonatal asphyxia; NK cells ; T-lymphocyte subsets ; Premature delivery; Immunity
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