Changes of MPV, RBP4, HbA1c, and Hcy in the severity of diabetic foot disease and its significance

Abstract

Objective To investigate the relationship between mean platelet volume (MPV), retinol binding protein 4 (RBP4), glycosylated hemoglobin (HbA1c), homocysteine (Hcy), and diabetic foot. Methods Sixty-seven patients with diabetic foot (DF group) diagnosed in our hospital from January 2015 to September 2016 were selected, 67 patients with diabetes mellitus as T2DM group, and 67 healthy controls as control group. MPV, RBP4, HbA1c, Hcy, and related blood glucose and lipid indicators were detected, and subgroup analysis was carried out according to Wagner classification. Results The levels of MPV, RBP4, HbA1c, and Hcy in DF group, T2DM group, and control group were (9.96±0.76)fl, (9.07±0.51)fl, (8.92±0.55)fl; (105.4±17.6)mg/L, (76.3±15.2)mg/L, (55.7±11.6)mg/L; (8.93±0.95)%, (7.30±0.77)%, (5.58±0.62)%; (18.42±4.48) μmol/L, (14.15±3.18) μmol/L, (9.20±2.71) μmol/L, respectively. The levels of MPV, RBP4, HbA1c, and Hcy in the DF group were significantly higher than those in the T2DM group and the control group (P<0.05); the levels of RBP4, HbA1c, and Hcy in the T2DM group were significantly higher than those in the control group (P<0.05). With the Wagner classification changed (Class I, II, III), the levels of MPV, RBP4, HbA1c, and Hcy in the diabetic patients gradually increased, with statistically significant differences between any two groups (P<0.05). Conclusion The levels of MPV, RBP4, HbA1c, and Hcy were significantly elevated in diabetic foot patients, which were associated with Wagner grading. Key words: Mean platelet volume (MPV); Retinol binding protein 4 (RBP4); Glycated hemoglobin (HbA1c); Homocysteine (Hcy); Diabetic foot