Abstract
The results of large studies have shown that women with the onset of menopause significantly increase the risk of developing cardiovascular disease.
 This is associated with the loss of the cardioprotective effect of estrogens and the formation of the so-called menopausal metabolic syndrome, which includes changes in the metabolism of lipids and lipoproteins, insulin and carbohydrates, as well as hemostasis and fibrinolysis. Simultaneous shutdown of ovarian function in women of reproductive age after total oophorectomy causes the early development of delayed climacteric disorders, including cardiovascular diseases. Timely administration of hormone replacement therapy can prevent the development of adverse metabolic changes and reduce cardiovascular risk.
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