Abstract
Objective: Metabolic disturbances such as dyslipidemia and liver enzymes changes may be associated with the risk for developing cardiac disorder as well as liver toxicity in PLWH having HAART. This study investigated the biological pattern of PLWH on effective antiretroviral therapy in the Democratic Republic of Congo.
Highlights
In Democratic Republic of the Congo (DR Congo), the prevalence of Human Immunodeficiency Virus (HIV) in adults (15-49 years) has decreased from 4% in 2005 to 0.8% in 2018[1,2,3]
As biological abnormalities may be associated with the risk for developing cardiac disorder and liver toxicity, this study investigated the biological pattern of people living with HIV on Highly Active Antiretroviral Therapy (HAART)
This study investigated the biochemical profile of 45 people living with HIV (PLWH) on HAART, with 40 HAART-naive PLWH as a control group
Summary
In Democratic Republic of the Congo (DR Congo), the prevalence of Human Immunodeficiency Virus (HIV) in adults (15-49 years) has decreased from 4% in 2005 to 0.8% in 2018[1,2,3]. The advent of effective antiretroviral therapy, known as Highly Active Antiretroviral Therapy (HAART), has substantially reduced HIV-associated mortality and morbidity in infected patients. HAART is recommended as a standard medication for the management of HIV infection [5,6]. As the number of people living with HIV (PLWH) on antiretroviral therapy is increasing, there is a need to improve a clinical, therapeutic drug and biological monitoring in low- and middle-income countries. Some PLWH would not adhere to HARRT due to the drug-related side effects such as lipodystrophy, peripheral neuropathy and anemia. These side effects and toxicity may lead to the drug therapy change and discontinuation [7,8]
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