Abstract
A post-tetanic membrane hyperpolarization following repetitive neuronal activity is a commonly observed phenomenon in the isolated frog spinal cord as well as in neurons of other nervous tissues. We have now used double-barrelled Na +- and K +-ion-sensitive microelectrodes to measure the intracellular Na +- and K +-concentrations and also the extracellular K +-concentration of lumbar spinal motoneurons during and after repetitive stimulation of a dorsal root. The results show that the posttetanic membrane hyperpolarization occurred at a time when the intracellular [Na +] reached its maximal value, intracellular [K +] had its lowest level and extracellular [K +] was still elevated. The hyperpolarization was blocked by ouabain and reduced by Li +. These data support the previous suggestion that an electrogenic Na +/K + pump mode may be the mechanism underlying the post-tetanic membrane hyperpolarization.
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