Abstract
ObjectiveThe human gut harbors diverse microbes that play a fundamental role in the well-being of their hosts. Microbes can cause autoimmunity, trigger autoimmunity in genetically susceptible individuals or prevent autoimmunity. There were reports about intestinal flora changes in Systemic Lupus Erythematosus (SLE) patients, but no data were available in northeast China. In this study, we investigated the intestinal flora changes of SLE patients in Heilongjiang province located in northeast China.MethodsFeces from 16 SLE patients and 14 healthy volunteers were employed to extract bacterial DNA, amplify 16s RNA of bacteria, and analyze the biological information by sequencing. The statistical analysis used the SPSS version of 17.ResultWe found that there were 1 phylums, 4 families and 9 genera in the intestinal flora of SLE patients. And the nine differences genera can be used to distinguish SLE patients from normal people.ConclusionWe found an increase of Proteobacteria and a decrease of Ruminococcaceae in SLE patients in different regions. In addition, we found that some proteins, enzymes, and diseases were significantly associated with SLE.
Highlights
The human gut harbors diverse microbes that play a fundamental role in the well-being of their hosts [1]
We found an increase of Proteobacteria and a decrease of Ruminococcaceae in Systemic lupus erythematosus (SLE) patients in different regions
We found that some proteins, enzymes, and diseases were significantly associated with SLE
Summary
The human gut harbors diverse microbes that play a fundamental role in the well-being of their hosts [1]. A growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis [3,4,5,6]. In Spain, the intestinal flora of SLE patients was characterized by a significantly lower Firmicutes/Bacteroidetes ratio and showed a depletion of Lachnospiraceae and Ruminococcaceae and an enrichment of Bacteroidaceae and Prevotellaceae [8]. In southern China, the intestinal flora of SLE patients was characterized by a significantly increase in Actinobacteria [9]. The SLE patients lived in southern of China showed the depletion of Firmicutes, enrichment of Bacteroidetes, Actinobacteria and Proteobacteria, and signifcant increases of the family Prevotellaceae[7]. In northeast China, there is a unique geographical environment and diet culture, there was a lack of research on the changes of intestinal flora in patients with SLE
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