Changes of IL-17 and VEGF levels in the relationship between the different stages of renal carcinoma expression and tumor angiogenesis

Abstract

Objective To study the changes of interleukin-17(IL-17) and vascular endothelial growth factor(VEGF) levels generated in different stages of renal carcinoma expression and tumor angiogenesis. Methods Sixty samples of renal carcinoma patients from October 2013 to December 2015 were collected.Sixty samples of healthy controls were sellected at the same time. Fasting blood was collected in all of the personnel, the level of IL-17 and VEGF in blood were determined by ELISA method.Acquisition cancer and normal tissues sliced, then the CD34 immunohistochemical experiments were made, and the micro vessel density (MVD) was counted under the microscope. Results The IL-17 and VEGF levels respectively increased with the changes of stages of renal carcinoma.But there were no significant difference between different pathological types of renal carcinoma.After the occurrence of renal carcinoma, MVD value significantly increased (P<0.05), but there was no significant difference in MVD value between different pathological types of renal carcinoma. Conclusions IL-17 and VEGF may be one of the reasons inducing renal carcinoma.But there are no direct relationship betwen IL-17, VEGF and the heterogeneity of renal carcinoma, and the levels of IL-17 and VEGF are positively correlated with MVD values. Key words: Interleukin-17; Vascular endothelial growth factor; Immunohistochemistry; Renal carcinoma; Tumor vessel