Abstract
[Aim] To investigate the action of cytokines in patients with chronic liver failure and to explore the roles of cytokines in chronic liver failure. [Methods] Thirty-one patients with chronic liver failure admitted from May 2006 to November 2009 were included. Thirty cases with mild to moderate chronic type B hepatitis admitted concomitantly were regarded as control. IL-1, TNF-alpha, IL-12, IL-10 Levels in serum was the factors to determine at clinical diagnosis and 2-week treatment. We analyzed levels of cytokines action in 31 chronic liver failure patients both at clinical diagnosis and 2-week treatment in comparison with control group. [Results] We analyzed IL-1 level in death group at clinical diagnosis and 2-week treatment were sig- nificant higher than in survival and control groups, furthermore it was also higher in survival group than in control group. At clinical diagnosis, TNF-alpha level in death group was higher than that in control. How- ever, there was no obviously difference between the death group and the survival group in TNF-alpha level. With the progression of the disease, TNF-alpha level was remarkably risen in death group, but decreased in survival group. IL-10 level was dramatically increased in death group, but no changed in survival group. IL-12 level in death group was higher than in survival group, but lower than in control group. [Conclusions] The levels of TNF-alpha, IL-1, IL-10 and IL-12 in patients with chronic liver failure was increased and the increase of IL-10 is secondary to elevation of IL-12.
Highlights
The pathogenesis of liver failure is very complicated, which involves virus-induced primary immuno-pathological damage, as well as cytokine-mediated effect
We investigated the levels of IL-1, TNF-alpha, IL-12 and IL-10 in serum in order to explore the roles of cytokines in pathogenesis and progression of chronic severe hepatitis
IL-1 level at clinical diagnosis stage was higher than after 2-week treatment, both in death group and survival group
Summary
The pathogenesis of liver failure is very complicated, which involves virus-induced primary immuno-pathological damage, as well as cytokine-mediated effect. Liver failure and multiple organ failure accompany with the level changed in cytokines [1]. Each cytokine factor has its own physiological function and interacts to each others, which is complicated to understand their roles. IL-12 has multiple biological activities, including anti-viral, anti-tumor and immunoregulation [2]. IL-12 reflects capabilities of human body in killing viruses. We investigated the levels of IL-1, TNF-alpha, IL-12 and IL-10 in serum in order to explore the roles of cytokines in pathogenesis and progression of chronic severe hepatitis
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