Abstract
Objective To study changes of growth associated protein(GAP-43) and effect of recombinant human erythropoietin (rhEPO) in rats after optic nerves crushed.Method The animal model of traumatic optic neuropathy was established,Sixty-three healthy aduh SD rats without eye diseases were divided into three groups randomly:control group,crush group and rhEPO group.The morphology of retina and optic nerve was observed.Changes of GAP-43 in optic nerve were studied with immunohistochemistry staining at 1 d,4 d,7 d,14 d and 28 d after crush.Results The pathological change of retina and optic nerve in rhEPO group reduced than in crush group.Immunohistochemistry results showed that there were no significant difference of GAP-43 expression between crush group and rhEPO group ( P ＞ 0.05 ) at 4 d,7 d after crush.However,the cxpression of GAP-43 in rhEFO group signmcatily increased than that of crush group at 14 d and 28 d after crush.(P＜0.05).Conclusion RhEPO may be helpful in repairing and regenerating of the retina ganglion cells and optic nerve after crush. Key words: Optic nerve injury; Growth associated protein - 43 ; Erythropoietin; Retinal ganglion cell
Published Version
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