Abstract
Background: Blood pressure (BP) has been proven to play an important role in changes of the morphology of a pulse waveform. However, the extent of change of the morphology because of BP signaling has yet to be accurately confirmed.Objectives: This study aims to disclose the accurate effect of BP on the changes in the morphology of the pulse waveform.Methods: Two dogs' invasive intraventricular BP (varied by ejecting different doses of epinephrine) and their femoral arterial pulse waveform (FAPW) signals were synchronously recorded. For each BP increase, a normalized single cardiac beat pulse from the FAPW signal was fitted by five Gaussian curves and the changes in the Gaussian parameters (height, peak position, and time support) were observed.Results: The height parameter increased while the position and time support parameters decreased with increasing systolic BP (SBP). The height ratio and the peak intervals between the first two components decreased with increasing SBP.Conclusions: These results may contribute to the better understanding of the underlying changes of arterial pulse properties at different BP levels and demonstrate the potential application value of the Gaussian fitting method for clinically assessing pulse morphology and evaluating the well-being of artery system.
Highlights
Arterial pulses are produced by the effects of cardiac ejection and the mechanical properties of the systemic arteries
A linear regression analysis was used to detect the statistical significance of the linear correlation between each Gaussian parameter and the systolic blood pressure (SBP) values
With the help of the synchronously recorded invasive Blood pressure (BP) signal from the left ventricle, this study extracted 15 parameters from five modeled Gaussian curves for the dogs’ femoral arterial pulse waveform (FAPW) signals, and providing the opportunities to disclose the accurate effect of BP on the changes in the morphology of pulse waveform
Summary
Arterial pulses are produced by the effects of cardiac ejection and the mechanical properties of the systemic arteries. Previous studies have confirmed that a surface-recorded pulse waveform is a superposition of both forward and backward components (Latham et al, 1985; Ting et al, 1990; Baruch et al, 2011). The forward component is derived from the blood ejection of the left ventricle, while the reflection components originate from the different reflection sites in the arterial system. The reflection sites are usually Tang and Liu. Changes in Femoral Pulse Characteristics ejecting different doses of epinephrine to induce varied BP values. The BP values in this study were measured in the left ventricle, which differs from the BP values in previous studies commonly measured in a peripheral artery. Blood pressure (BP) has been proven to play an important role in changes of the morphology of a pulse waveform. The extent of change of the morphology because of BP signaling has yet to be accurately confirmed
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