Abstract
Dorsal root potentials (DRPs) and changes of extracellular K + accompanying orthodromic stimulation were studied under high Mg 2+ concentration in isolated spinal cord of the frog. Under 20 mM MgSO 4 when synaptic transmission was blocked the amplitude of DRPs, evoked by a single volley in a dorsal root, decreased to 5–15% of the control and the transient increase of extracellular potassium concentration [K] e evoked by 100 Hz orthodromic stimulation decreased to 10–15%. It is suggested that the DRPs, resistant to high Mg 2+ concentration, are produced by transient increase of K + that leaks from primary afferents.
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