Changes of Coagulation and Fibrinolysis in Patients with Liver Cirrhosis

Abstract

Liver disease is associated with complex coagulation and fibrinolytic defects. In this study we assayed molecular marker levels for coagulation and fibrinolysis, i. e. plasma fibrinopeptide A (FPA), fibrinopeptide Bβ1-42 (Bβ1-42), fibrino peptide Bβ15-42 (Bβ15-42), tissue-type plasminogen activator antigen (t-PA antigen) and activity (t-PA activity), plasminogen activator inhibitor (PAI), D-dimer, plasminogen, α2 plasmin inhibitor (α2 PI), α2 PI-plasmin-complex (PIC), ATIII and serum FDP-E in 31 patients with liver cirrhosis for investigated the state of coagulation and fibrinolyssis in liver cirrhosis.All these molecular markers changed significantly compared with the value in normal subjects. As for coagulation, hypercoagulable state was observed because of increment FPA level and one of the reasons of this state maight be decrease of ATIII synthesis. As for fibrinolytic state, accelerated fibrinolysis was observed because of increment of PIC, Bβ1-42, D-dimer, FDP-E, Bβ15-42. In addition, these changes might be induced through accelerated secondary fibrinolysis, increment of t-PA by decleased clearance of circulating PA and diminished α2 PI synthesis.And the variation of t-PA antigen level was well correlated to plasminogen, α2 PI, ATIII and Ch-E, measuring of t-PA antigen level was useful to evaluate liver function in the patients with liver cirrhosis.