Changes of cerebrovascular hemodynamic accumulative scores in health checkup population and their influencing factors

Abstract

Objective To investigate the changes of cerebrovascular hemodynamic accumulative score in health checkup population and their influencing factors. Methods A total of 1 840 people aged 23-88 years were checked by CVHI and accumulative scores were calculated. The general information, blood biochemistry, highly sensitive C-reaction protein (hs-CRP), homocysteine (Hcy), carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (baPWV) were also collected during the corresponding period. Results The proportion of abnormal CVHI accumulative score (<75 points) was increasing with age. Compared with the normal CVHI accumulative score (≥75 points) group, the proportion of hypertensive disease, diabetes and stroke family history was significantly higher in the abnormal group (P< 0.05). In addition, the levels of age, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), hs-CRP, Hcy, CIMT and baPWV were also significantly increased in the abnormal group (P<0.05). Correlation analysis showed a negative correlation between CVHI accumulative score and age, history of hypertension, diabetes, BMI, WC, SBP, DBP, LDL-C, TG, FPG, hs-CRP, Hcy, baPWV (P< 0.05), but a positive correlation with HDL-C (P<0.05). Multiple factor analysis determined that age [OR(95%CI):1.017(1.002-1.033)], history of hypertension [OR(95%CI):1.510(1.096-2.081)], BMI [OR(95%CI):1.235(1.135-1.344)], SBP [OR(95%CI):1.044(1.030-1.059)], LDL-C [OR(95%CI):1.673(1.444-1.937)], TG [OR(95%CI):1.116(1.035-1.204)], hs-CRP [OR(95%CI):1.037(1.003-1.073)], Hcy [OR(95%CI):1.099(1.062-1.136)], baPWV [OR(95%CI):1.001(1.000-1.002)] were being selected into the regression model (P<0.05), and they were independent influencing factors of decreased CVHI accumulative scores. Conclusion The decreased CVHI accumulative score has a significant relationship with exposure levels of risk factors in stroke. Therefore, we conclude that the detection of CVHI is a convenient and feasible method to screen high risk individuals for stroke in middle and old aged population undergoing medical examination. Key words: Stroke; Hemodynamics; Risk factors