Abstract
Aim: To investigate the changes of carbonyl stress parameters in rats with combined streptozotocin induced diabetes (STZD, hyperglycemia model) and glycerol stimulated rhabdomyolysis (RM, oxidative stress mode l). Methodology: RM was induced by glycerol injection and confirmed by changes of heme oxygenase activity, creatine kinase activity, total heme, creatinine, uric acid, urea and bilirubin. STZD was induced by streptozotocin injection and proved by increasi ng of glucose levels. Carbonyl stress development was determined by total aldehyde levels, TBARS, protein CO group levels, N(6) Carboxymethyllysine and low - molecular - weight SH groups in blood plasma and liver tissue. Results: A significant increase of carb onyl stress parameters was recorded in RM and STZD rat groups compared with their relative control levels. In animals subjected to the combined induction of
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