Changes of blood glucose and electrolyte levels after neonatal asphyxia and its clinical significant

Abstract

Objective To investigate the changes of blood glucose and electrolyte levels after neonatal asphyxia and its clinical significance. Methods A total of 240 asphyxiated neonates admitted to the Department of Paediatrics in Huangshi Central Hospital from January 2017 to October 2018 were selected as the objects. According to Apgar scoring criteria, they were divided into mild asphyxiation group (130 cases) and severe asphyxia group (110 cases). And 130 healthy neonates in the same period were selected as the control group. Five ml venous blood was collected from three groups of newborns and the serum was separated by 2 800 r/min centrifugation for detection and comparison, the blood glucose and serum K+, Na+, Cl- and Ca2+ of the three groups of newborns were compared. Results There were significant differences in blood glucose among the three groups ( P all 0.05), the increasing order of hypoglycaemia was control group, severe asphyxia group and mild asphyxia group. There was no significant difference in K+ concentration among the three groups (P> 0.05), but there was a significant difference in Na+, Cl-, Ca2+ concentration among the three groups (P< 0.05). Conclusions The disorder of blood sugar and electrolyte is often accompanied by neonatal asphyxia. Severe asphyxia may also lead to multiple organ damage in neonates. The degree of electrolyte disturbance can reflect the severity of neonatal asphyxia, so clinical workers should pay close attention to the changes of blood sugar and electrolyte in neonates. Key words: Newborn; Asphyxia; Abnormal blood glucose; Electrolyte disturbance